

DIGITAL CONTENT CENTER: HYPOPHOSPHATASIA (HPP)
| HPP Publications | HPP Patient Videos | ESPE-ESE 2025 HPP Symposium
Hypophosphatasia (HPP) is a rare, inherited, metabolic, systemic disease caused by deficient activity of the alkaline phosphatase (ALP) enzyme. HPP affects people of all ages with a broad spectrum of skeletal and nonskeletal clinical manifestations, high disease burden, and substantial negative impact on quality of life.
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1. Bangura A et al. Cureus 2020;12(6):e8594. 2. Rockman-Greenberg C. Pediatr Endocrinol 2013;10 Suppl 2:380-388. 3. Whyte MP. J Clin Endocrinol Metab 2013; 98(12):4606-4612. 4. Linglart A, Biosse-Duplan M. Curr Osteoporos Rep. 2016;14:95-105. . 5. Martos-Moreno GA et al. Horm Res Paediatr. 2024;97(3):233-242.

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